| Place | Time | Swimmer (Yr) | School | City | State |
| 1 | 4:28.71 | Katie Ledecky (11) | Stone Ridge School | Bethesda | MD |
| 2 | 4:40.04 | Courtney Harnish (9 ) | West York Area High School | York | PA |
| 3 | 4:44.06 | Isabella Rongione (9 ) | Langley High School | McLean | VA |
| 4 | 4:44.53 | Ally Howe (12) | Sacred Heart Preparatory | Atherton | CA |
| 5 | 4:44.92 | Megan Byrnes (10) | Oakton High School | Vienna | VA |
| 6 | 4:45.16 | Amanda Richey (12) | Boulder High School | Boulder | CO |
| 7 | 4:45.67 | Cecelia Williams (12) | Lawton Chiles High School | Tallahassee | FL |
| 8 | 4:45.82 | Leah Stevens (11) | Sacred Heart Academy | Louisville | KY |
| 9 | 4:46.29 | Sierra Schmidt (9 ) | Germantown Academy | Fort Washington | PA |
| 10 | 4:46.85 | Brooke Lorentzen (12) | Capistrano Valley High School | Mission Viejo | CA |
| 11 | 4:46.93 | Kirsten Jacobsen (10) | Barrington High School | Barrington | IL |
| 12 | 4:47.11 | Alexandra Aitchison (11) | East Lake High School | Tarpon Springs | FL |
| 13 | 4:47.21 | Moriah Simonds (10) | Granada High School | Livermore | CA |
| 14 | 4:47.37 | Katie Duggan (11) | Lake Highland Preparatory School | Orlando | FL |
| 15 | 4:47.39 | Sandra Soe (11) | Pioneer High School | San Jose | CA |
| 16 | 4:47.81 | Chenoa Devine (10) | Davis Senior High School | Davis | CA |
| 17 | 4:47.83 | Hannah Kukurugya (9 ) | Crown Point High School | Crown Point | IN |
| 18 | 4:47.92 | Elizabeth Stinson (11) | Harpeth Hall School | Nashville | TN |
| 19 | 4:48.20 | Zoe Thatcher (12) | Mason High School | Mason | OH |
| 20 | 4:48.62 | Ellen Berdusco (11) | Saint Stephen's Episcopal School | Bradenton | FL |
| 21 | 4:48.80 | Emily Moser (11) | Fishers High School | Fishers | IN |
| 22 | 4:49.03 | Lindsay Stone (9 ) | Pittsford Central Schools | Pittsford | NY |
| 23 | 4:49.16 | Spence Atkins (10) | Riverview High School | Sarasota | FL |
| 24 | 4:49.22 | Kaersten Meitz (12) | Waukesha South High School | Waukesha | WI |
| 25 | 4:49.24 | Molly Treble (12) | Massapequa High School | Massapequa Park | NY |
| 26 | 4:49.44 | Brittney Beetcher (9 ) | Fairview High School | Boulder | CO |
| 27 | 4:49.62 | Jessica Sloan (12) | Magnolia West High School | Magnolia | TX |
| 28 | 4:49.67 | Taylor Ault (9 ) | Sonora High School | La Habra | CA |
| 29 | 4:49.73 | Jennifer Campbell (11) | Gunn High School | Palo Alto | CA |
| 30 | 4:49.94 | Anna Jahns (11) | Brookwood High School | Snellville | GA |
| 31 | 4:50.34 | Sammie Hashbarger (12) | McKinney High School | McKinney | TX |
| 32 | 4:50.88 | Abby Jagdfeld (12) | Waukesha South High School | Waukesha | WI |
| 33 | 4:50.95 | Kendall Brent (10) | Fort Myers High School | Fort Myers | FL |
| 34 | 4:51.11 | Lisa Kaunitz (10) | Monta Vista High School | Cupertino | CA |
| 35 | 4:51.27 | Karlee Carminati (9 ) | Germantown Academy | Fort Washington | PA |
| 36 | 4:51.34 | Verity Abel (12) | Staples High School | Westport | CT |
| 37 | 4:51.47 | Abbey Schneider (11) | Fishers High School | Fishers | IN |
| 38 | 4:51.67 | Sydney Modeas (12) | Clarence High School | Clarence | NY |
| 39 | 4:51.68 | Alexandria Wittman (12) | Osceola High School | Seminole | FL |
| 40 | 4:51.75 | Brittany Kampfer (10) | Mater Dei High School | Santa Ana | CA |
| 41 | 4:51.84 | Rebecca Postoll (11) | Charlotte Catholic High School | Charlotte | NC |
| 42 | 4:51.93 | Amanda Nunan (9 ) | Ocean City High School | Ocean City | NJ |
| 43 | 4:52.02 | Emily Meckstroth (11) | Penn High School | Mishawaka | IN |
| 44 | 4:52.06 | Summer Brown (12) | Western High School | Russiaville | IN |
| 45 | 4:52.14 | Claire Doerr (10) | Hawken School | Gates Mills | OH |
| 46 | 4:52.27 | Anna Quinn (12) | Thousand Oaks High School | Thousand Oaks | CA |
| 47 | 4:52.50 | Nika Fellows (12) | La Cueva High School | Albuquerque | NM |
| 48 | 4:52.51 | Grace Tierney (11) | Loyola Academy | Wilmette | IL |
| 49 | 4:52.55 | Sabrina Mortell (12) | Cumberland Valley High School | Mechanicsburg | PA |
| 50 | 4:52.56 | Jennifer Smith (12) | Upper Arlington High School | Upper Arlington | OH |
| 51 | 4:52.59 | Hanna Huston (11) | James E. Taylor High School | Katy | TX |
| 52 | 4:52.63 | Kathryn McLaughlin (11) | Santa Margarita Catholic High School | Rancho Santa Margarita | CA |
| 53 | 4:52.71 | Brittany Kahn (11) | Jserra Catholic High School | San Juan Capistrano | CA |
| 54 | 4:52.76 | McKenna Meyer (10) | Galena High School | Reno | NV |
| 55 | 4:52.79 | Jordan Anderson (11) | Granite Bay High School | Granite Bay | CA |
| 56 | 4:52.96 | Kira Webster (12) | University High School | Normal | IL |
| 57 | 4:52.99 | Erin Voss (10) | Northampton High School | Northampton | MA |
| 58 | 4:53.05 | Summer Finke (11) | Countryside High School | Clearwater | FL |
| 59 | 4:53.08 | Erin Earley (9 ) | Hopkins School | New Haven | CT |
| 60 | 4:53.12 | Abbey Erwin (9 ) | Boise High School | Boise | ID |
| 61 | 4:53.21 | Erin Emery (11) | Palo Verde High School | Las Vegas | NV |
| 62 | 4:53.34 | Kelsie Walker (12) | Carbondale Community High School | Carbondale | IL |
| 63 | 4:53.38 | Haley Yelle (9 ) | Mansfield Legacy High School | Mansfield | TX |
| 64 | 4:53.39 | Sydney Franzen (11) | Santa Margarita Catholic High School | Rancho Santa Margarita | CA |
| 65 | 4:53.47 | Mary Katie Woods (10) | Livermore High School | Livermore | CA |
| 66 | 4:53.63 | Erica Laning (9 ) | Farragut High School | Knoxville | TN |
| 67 | 4:53.64 | Brigid McNally (10) | Ventura High School | Ventura | CA |
| 68 | 4:53.68 | Sydney King (12) | Granville High School | Granville | OH |
| 69 | 4:53.72 | Nicole Smith (11) | Munster High School | Munster | IN |
| 70 | 4:53.83 | Sydney Larson (10) | Rio Americano High School | Sacramento | CA |
| 71 | 4:53.88 | Allison Goldblatt (9 ) | W. T. Woodson High School | Fairfax | VA |
| 72 | 4:53.91 | Claire Therien (10) | San Ramon Valley High School | Danville | CA |
| 73 | 4:53.95 | Bridget Ritter (12) | Bellaire High School | Houston | TX |
| 74 | 4:54.05 | Emma Cole (9 ) | Walton High School | Marietta | GA |
| 74 | 4:54.05 | Robyn Dryer (11) | West Springfield High School | Springfield | VA |
| 76 | 4:54.16 | Zarena Brown (10) | Pomona High School | Arvada | CO |
| 77 | 4:54.17 | Natalie Clausen (11) | Waukesha South High School | Waukesha | WI |
| 78 | 4:54.27 | Karli Thuen (11) | Jserra Catholic High School | San Juan Capistrano | CA |
| 79 | 4:54.29 | Morgan Tacik (10) | West Forsyth High School | Clemmons | NC |
| 80 | 4:54.30 | Anastasia Henderson (11) | San Ramon Valley High School | Danville | CA |
| 81 | 4:54.34 | Kaitlyn Hauser (10) | Estero High School | Estero | FL |
| 82 | 4:54.42 | Emma King (11) | Centerville High School | Centerville | OH |
| 82 | 4:54.42 | Emmaline Peterson (9 ) | Hickory High School | Hickory | NC |
| 84 | 4:54.60 | Claire Gilmore (11) | Mariemont High School | Cincinnati | OH |
| 85 | 4:54.78 | Kira Zubar (12) | Eden Prairie High School | Eden Prairie | MN |
| 86 | 4:54.94 | Rebecca Upton (12) | Southlake Carroll High School | Southlake | TX |
| 87 | 4:54.98 | Joy Field (9 ) | Magnolia High School | Magnolia | TX |
| 88 | 4:55.00 | Mary Katherine Kish (12) | The Collegiate School | Richmond | VA |
| 89 | 4:55.05 | Courtney Evensen (11) | Robbinsdale Armstrong High School | Plymouth | MN |
| 89 | 4:55.05 | Paige Kelly (12) | Hudson High School | Hudson | OH |
| 91 | 4:55.22 | Kat Wickham (12) | Palm Springs High School | Palm Springs | CA |
| 92 | 4:55.27 | Mary Hinton (12) | Heritage High School | Littleton | CO |
| 93 | 4:55.43 | Amelia Draney (12) | Desert Hills High School | St George | UT |
| 94 | 4:55.46 | Cameron Smith (9 ) | Seattle Preparatory School | Seattle | WA |
| 95 | 4:55.47 | Payton Neff (9 ) | The Woodlands High School | The Woodlands | TX |
| 96 | 4:55.51 | Tommie Dillione (12) | Council Rock North High School | Newtown | PA |
| 97 | 4:55.74 | Isabel Whited (10) | Pinnacle High School | Phoenix | AZ |
| 98 | 4:55.80 | Morgan Smith (11) | Montclair Kimberley Academy | Montclair | NJ |
| 99 | 4:55.82 | Bryn Handley (12) | Du Pont Manual High School | Louisville | KY |
| 100 | 4:55.89 | Maryso Arce (11) | St. Ignatius College Prep | Chicago | IL |